Select CCS

Many IVF programs still rely heavily on judging an embryo’s potential to implant based on how it looks under the microscope–essentially judging a book by its cover. RMANJ understands that with embryos, there’s much more than meets the eye, which is why we developed SelectCCS, a 24-chromosome screening process that safely identifies chromosomal abnormalities in the embryo at the molecular level. Comprehensive Chromosome Screening (CCS) can help improve implantation rates, reduce miscarriage rates, and reduce the risk of multiples after IVF.

Current data suggests that 50-70% of miscarriages are due to embryos with too few or too many chromosomes. At the same time we know that the frequency of aneuploidy increases with age. Using a more comprehensive and evidence-based approach like SelectCCS during the embryo selection process can improve safety and efficacy of your IVF cycle. SelectCCS has demonstrated to be 98% accurate in determining aneuploidy1,2.

In 2013 RMANJ donated SelectCCS to the Foundation for Embryonic Competence (FEC), a non-profit organization dedicated to improving outcomes and advancing knowledge in the areas of research, diagnosis, and education. SelectCCS is owned and operated by the Foundation for Embryonic Competence (www.feclabs.org).

SelectCCS also makes the promise of single embryo transfer (SET) a reality, providing uncompromising success rates without complications often associated with twin pregnancies and deliveries. “Advances in screening technology that allow us to rapidly and safely determine if an embryo is chromosomally normal now make ‘SET’ a more viable pathway to pregnancy for couples undergoing IVF. We can reduce the risk of twins, which tend to be more complicated pregnancies, but thanks to improved freezing technology not reduce the chance of having two children if that’s what a couple wants in the long run”3.

Learn how SET can make the promise of “one embryo, one healthy baby” a reality3.

Works Sited:

1. Scott RT, Jr., Upham K, Forman E, Hong K, Scott K, Taylor D, Tao X, Treff NR. Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilitzation implantation and delivery rates; a randomized controlled trial. Fertil Steril 2013. In Press.

2. Richard T. Scott Jr., M.D., Kathleen Ferry, B.S., Jing Su, M.S., Xin Tao, M.S., Katherine Scott, M.S., and Nathan R. Treff, Ph.D. Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study. Fertility and Sterility. April 2012; 97(4):87-5.

3.Forman, E.J., Tao, X., Ferry, K.M., Taylor, D., Treff, N.R., Scott, R.T. Single Embryo Transfer with Comprehensive Chromosome Screening Results in Improved Ongoing Pregnancy Rates and Decreased Miscarriage Rates. Human Reproduction. April 2012; 27(4): 1217-22.

Please note that a comparison of clinic success rates may not be meaningful because a patient’s medical characteristics, treatment approaches and entrance criteria for ART may vary from clinic to clinic. We encourage you to learn more at www.sart.org.

Have questions regarding Comprehensive Chromosome Screening (CCS)? For more information, please contact us today.